Targeting CSC Dormancy

Cancer stem cells (CSCs) can enter a dormant state, allowing them to evade treatments and later reinitiate tumor growth. This track focuses on understanding the mechanisms that regulate CSC dormancy, including signals from the microenvironment and intrinsic genetic factors. Researchers explore how dormant CSCs resist conventional therapies, which typically target actively dividing cells. Developing therapies that can either awaken dormant CSCs, making them vulnerable to treatment, or eliminate them while dormant, could significantly improve long-term survival rates for cancer patients. This research aims to prevent tumor recurrence by targeting the CSCs that remain dormant but capable of causing relapse.

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