Role of EMT in CSC Plasticity

The epithelial-mesenchymal transition (EMT) is a process by which cancer stem cells (CSCs) acquire enhanced migratory and invasive properties, contributing to metastasis. This track explores the role of EMT in CSC plasticity and how it allows CSCs to switch between epithelial and mesenchymal states. Researchers investigate how EMT-related signaling pathways, such as TGF-β and ZEB1, regulate CSC behavior and promote tumor progression. Targeting EMT in CSCs could help prevent metastasis and improve treatment responses by limiting the cells’ ability to adapt and spread. This research aims to develop novel therapies that block EMT in CSCs, reducing their metastatic potential.

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