Drug Resistance Mechanisms in CSCs

Cancer stem cells (CSCs) are notoriously resistant to standard cancer therapies, making them a major contributor to treatment failure and relapse. This track delves into the specific mechanisms that allow CSCs to resist chemotherapy and radiation, including the overexpression of drug efflux pumps, enhanced DNA repair, and activation of survival pathways. Researchers explore strategies to overcome these resistance mechanisms by developing drugs that target CSC-specific survival pathways. By identifying and inhibiting the factors that protect CSCs from treatment, this research aims to improve the efficacy of existing cancer therapies and reduce the likelihood of disease recurrence.

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