Therapy Resistance and CSCs

A major challenge in cancer treatment is the ability of CSCs to resist chemotherapy and radiation. This research track investigates the mechanisms behind this resistance, focusing on CSCs' ability to remain in a quiescent state, enhancing their DNA repair capabilities and activating drug efflux pumps to remove chemotherapeutic agents. Additionally, CSCs' high expression of survival pathways and anti-apoptotic proteins makes them less susceptible to conventional treatments. This track explores how these intrinsic properties of CSCs contribute to disease recurrence and poor patient prognosis. The aim is to discover novel therapeutic approaches that target these resistance mechanisms, ensuring that CSCs are eradicated alongside the bulk tumor cells, thereby preventing relapse and metastasis.

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