Evolutionary Dynamics of Cancer Stem Cell Populations

Cancer stem cell populations evolve continuously through biological selection and adaptation. Genetic variation, epigenetic flexibility, and environmental pressure drive population level changes over time. Cells with advantageous traits preferentially survive and expand, reshaping tumor composition. Evolutionary dynamics are influenced by niche availability, resource competition, and cellular interactions. Cancer stem cells act as reservoirs of diversity, generating progeny with varied characteristics. This ongoing evolution results in dynamic tumor systems rather than static structures. Cellular plasticity accelerates adaptation by enabling rapid phenotype switching. From a biological perspective, cancer progression reflects an evolutionary process governed by selection, variation, and inheritance within stem cell populations. Understanding these dynamics provides a comprehensive framework for interpreting tumor behavior at the cellular level.

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