CSC Niche and Hypoxia

The microenvironment, or niche, of cancer stem cells (CSCs) plays a pivotal role in maintaining their stemness and promoting tumor growth. Hypoxia, or low oxygen levels, is a critical feature of the CSC niche that drives their survival and resistance to therapies. This track examines how hypoxia-induced signaling pathways, such as HIF-1α, enhance CSC stemness and contribute to metastasis. Researchers aim to develop strategies to disrupt the hypoxic niche, thereby sensitizing CSCs to chemotherapy and radiation. Understanding the unique features of the CSC niche can help identify new therapeutic targets that prevent CSCs from thriving under stress conditions, improving treatment outcomes.

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