Cellular Stress Response in Cancer Stem Cells

Cancer stem cells are exposed to continuous biological stress arising from metabolic imbalance, hypoxia, and genomic instability. To survive, they activate adaptive stress response mechanisms that preserve cellular integrity. These responses include modulation of protein folding, metabolic regulation, and redox balance. Cancer stem cells maintain controlled levels of reactive oxygen species to prevent damage while supporting signaling functions. Stress response pathways also influence cell cycle control and quiescence. Persistent activation of these mechanisms enables long term survival under adverse conditions. However, adaptive responses also increase tolerance to instability, allowing accumulation of mutations. From a biological standpoint, stress adaptation represents a survival strategy that supports stem cell persistence and tumor evolution.

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