Quiescence and Dormancy in Cancer Stem Cells

Quiescence is a reversible non proliferative state that allows cancer stem cells to survive unfavorable biological conditions. Unlike actively dividing tumor cells, quiescent cancer stem cells remain metabolically active but do not undergo cell division. This state protects them from cellular stress and preserves long term self renewal capacity. Quiescence is regulated by cell cycle control mechanisms, metabolic adaptation, and transcriptional repression of proliferation associated genes. Dormant cancer stem cells can persist for extended periods within tumors, contributing to long term disease maintenance. Environmental signals such as nutrient availability and cellular crowding influence entry into and exit from quiescence. From a biological standpoint, quiescence represents a survival strategy that allows cancer stem cells to balance growth with preservation. Studying this state enhances understanding of tumor persistence and cellular longevity.

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