Cancer Stem Cell & Oncology Research

Molecular Signaling in CSCs

CSCs rely on several critical signaling pathways that regulate their survival, proliferation, and ability to resist therapies. This track focuses on understanding key molecular pathways like Wnt/β-catenin, Hedgehog, Notch, and TGF-β, which govern CSC behavior. The dysregulation of these pathways often results in uncontrolled cell growth, maintenance of stemness, and enhanced survival capabilities of CSCs. Researchers aim to identify how mutations or aberrant signaling contribute to cancer initiation and metastasis. Targeting these signaling pathways holds great promise for therapies that selectively eliminate CSCs without harming normal stem cells. By understanding the molecular underpinnings of CSC regulation, novel inhibitors and therapeutic strategies can be developed to block CSC-driven tumorigenesis and overcome treatment resistance, leading to better clinical outcomes.