CSC-Mediated Immunosuppression

Cancer stem cells (CSCs) are adept at creating an immunosuppressive microenvironment, enabling them to evade immune attack. This track focuses on how CSCs manipulate immune cells, such as T-cells, macrophages, and dendritic cells, to suppress anti-tumor immune responses. Researchers explore how CSCs produce immunosuppressive factors like IL-10, TGF-β, and PD-L1, which inhibit immune cell activation and function. By targeting these immunosuppressive mechanisms, new therapeutic strategies could be developed to enhance the immune system’s ability to recognize and eliminate CSCs. This research highlights the importance of combining immunotherapy with CSC-targeted approaches to improve cancer treatment outcomes.

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