Ovarian Cancer Stem Cells

According to the cancer stem cell (CSC) paradigm, cancer cells that have not undergone differentiation and are capable of self-renewal and tumor-initiating activity are what sustain and feed the growth and spread of tumors. Ovarian cancer is regarded as a model case of CSC-driven illness, which is supported by its biological characteristics and clinical evolution. Indeed, ovarian cancer stem cells (OCSC) would explain not only the initial tumor growth, the peritoneal spread, and also the relapse, but also the emergence of chemo resistance, having significant implications for the therapy of this fatal disease.




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