Lung Cancer Stem Cells

Despite substantial advancements in staging and treatments, lung cancer's high incidence and recurrence still contribute significantly to cancer-related mortality. According to recent research, stem cells located throughout the airways may start the development of cancer. These alleged stem cells continue to exhibit protumorigenic traits as a high ability for multipotent differentiation, resistance to drugs, and a prolonged lifespan in comparison to other cells. Different cancer types maintain stem cell signaling and differentiation pathways, and instability of this machinery may contribute to the maintenance of cancer stem cells. One area of active research is the characterization of cancer stem cells, which is essential for creating new treatments. The current understanding of stem cell signaling pathways and cell markers used to detect cancer stem cells is summarized in this article.


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